MovDisordV3, Main, Exploration, bibRecord, 002513

LRRK2 R1628P Variant Is a Risk Factor of Parkinson's Disease Among Han-Chinese from Mainland China

Identifieur interne : 002513 ( Main/Exploration ); précédent : 002512; suivant : 002514

LRRK2 R1628P Variant Is a Risk Factor of Parkinson's Disease Among Han-Chinese from Mainland China

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0472199

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Facteur risque, Chinois, Chine.

English descriptors

KwdEn :
- China, Chinese, Nervous system diseases, Parkinson disease, Risk factor.

Abstract

Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han-Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60-6.17, P < 0.01]. Considering the age at onset, this difference was found only in late-onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90-7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han-Chinese population.

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">LRRK2 R1628P Variant Is a Risk Factor of Parkinson's Disease Among Han-Chinese from Mainland China</title>
<author><name sortKey="Zijuan Zhang" sort="Zijuan Zhang" uniqKey="Zijuan Zhang" last="Zijuan Zhang">ZIJUAN ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, West China Hospital, Sichuan University</s1>
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<author><name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, West China Hospital, Sichuan University</s1>
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<author><name sortKey="Yingcheng Wang" sort="Yingcheng Wang" uniqKey="Yingcheng Wang" last="Yingcheng Wang">YINGCHENG WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, West China Hospital, Sichuan University</s1>
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<author><name sortKey="Yanming Xu" sort="Yanming Xu" uniqKey="Yanming Xu" last="Yanming Xu">YANMING XU</name>
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<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guanggu Yuan" sort="Guanggu Yuan" uniqKey="Guanggu Yuan" last="Guanggu Yuan">GUANGGU YUAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, West China Hospital, Sichuan University</s1>
<s2>Chengdu</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xueye Mao" sort="Xueye Mao" uniqKey="Xueye Mao" last="Xueye Mao">XUEYE MAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, West China Hospital, Sichuan University</s1>
<s2>Chengdu</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rong Peng" sort="Rong Peng" uniqKey="Rong Peng" last="Rong Peng">RONG PENG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, West China Hospital, Sichuan University</s1>
<s2>Chengdu</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>China</term>
<term>Chinese</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Facteur risque</term>
<term>Chinois</term>
<term>Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han-Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60-6.17, P < 0.01]. Considering the age at onset, this difference was found only in late-onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90-7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han-Chinese population.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>Singapour</li>
<li>Suisse</li>
</country>
<region><li>Canton de Berne</li>
</region>
<settlement><li>Berne</li>
</settlement>
<orgName><li>Université de Berne</li>
<li>Université nationale de Singapour</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zijuan Zhang" sort="Zijuan Zhang" uniqKey="Zijuan Zhang" last="Zijuan Zhang">ZIJUAN ZHANG</name>
</noRegion>
<name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name>
<name sortKey="Guanggu Yuan" sort="Guanggu Yuan" uniqKey="Guanggu Yuan" last="Guanggu Yuan">GUANGGU YUAN</name>
<name sortKey="Jinhong Zhang" sort="Jinhong Zhang" uniqKey="Jinhong Zhang" last="Jinhong Zhang">JINHONG ZHANG</name>
<name sortKey="Jinhong Zhang" sort="Jinhong Zhang" uniqKey="Jinhong Zhang" last="Jinhong Zhang">JINHONG ZHANG</name>
<name sortKey="Rong Peng" sort="Rong Peng" uniqKey="Rong Peng" last="Rong Peng">RONG PENG</name>
<name sortKey="Wenjun Chen" sort="Wenjun Chen" uniqKey="Wenjun Chen" last="Wenjun Chen">WENJUN CHEN</name>
<name sortKey="Wenjun Chen" sort="Wenjun Chen" uniqKey="Wenjun Chen" last="Wenjun Chen">WENJUN CHEN</name>
<name sortKey="Xingkai An" sort="Xingkai An" uniqKey="Xingkai An" last="Xingkai An">XINGKAI AN</name>
<name sortKey="Xueye Mao" sort="Xueye Mao" uniqKey="Xueye Mao" last="Xueye Mao">XUEYE MAO</name>
<name sortKey="Yan Wu" sort="Yan Wu" uniqKey="Yan Wu" last="Yan Wu">YAN WU</name>
<name sortKey="Yanming Xu" sort="Yanming Xu" uniqKey="Yanming Xu" last="Yanming Xu">YANMING XU</name>
<name sortKey="Yingcheng Wang" sort="Yingcheng Wang" uniqKey="Yingcheng Wang" last="Yingcheng Wang">YINGCHENG WANG</name>
<name sortKey="Yingru Gou" sort="Yingru Gou" uniqKey="Yingru Gou" last="Yingru Gou">YINGRU GOU</name>
</country>
<country name="Suisse"><region name="Canton de Berne"><name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name>
</region>
</country>
<country name="Singapour"><noRegion><name sortKey="Burgunder, Jean Marc" sort="Burgunder, Jean Marc" uniqKey="Burgunder J" first="Jean-Marc" last="Burgunder">Jean-Marc Burgunder</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

LRRK2 R1628P Variant Is a Risk Factor of Parkinson's Disease Among Han-Chinese from Mainland China

LRRK2 R1628P Variant Is a Risk Factor of Parkinson's Disease Among Han-Chinese from Mainland China

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